Abstract
Myristoyl-CoA:Protein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid, myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for anticancer, antiviral and antifungal agents. Recent N-myristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.
MeSH terms
-
Acyltransferases / antagonists & inhibitors*
-
Acyltransferases / metabolism*
-
Animals
-
Antifungal Agents / metabolism
-
Antifungal Agents / pharmacology
-
Antineoplastic Agents / metabolism
-
Antineoplastic Agents / pharmacology
-
Antiparasitic Agents / metabolism
-
Antiparasitic Agents / pharmacology
-
Antiviral Agents / metabolism
-
Antiviral Agents / pharmacology
-
Humans
-
Sensitivity and Specificity
Substances
-
Antifungal Agents
-
Antineoplastic Agents
-
Antiparasitic Agents
-
Antiviral Agents
-
Acyltransferases
-
glycylpeptide N-tetradecanoyltransferase