Psychollatine, a glucosidic monoterpene indole alkaloid from Psychotria umbellata

V A Kerber; C S Passos; H Verli; A G Fett-Neto; J P Quirion; A T Henriques

doi:10.1021/np0703951

Psychollatine, a glucosidic monoterpene indole alkaloid from Psychotria umbellata

J Nat Prod. 2008 Apr;71(4):697-700. doi: 10.1021/np0703951. Epub 2008 Feb 21.

Authors

V A Kerber¹, C S Passos, H Verli, A G Fett-Neto, J P Quirion, A T Henriques

Affiliation

¹ Faculdade de Farmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Ipiranga, 2752, Porto Alegre, 90610-000, Brazil.

PMID: 18288808
DOI: 10.1021/np0703951

Abstract

A monoterpene indole alkaloid, psychollatine ( 1), was isolated from Psychotria umbellata leaves. Its structure was characterized by interpretation of spectroscopic data and by comparison of its NMR data with those of croceaine A ( 2) from Palicourea crocea. The configuration of psychollatine ( 1) was established by NOE difference and circular dichroism (CD) techniques, while its conformation was evaluated through molecular modeling studies and NMR coupling constants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Brazil
Glycosides / chemistry
Glycosides / isolation & purification*
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Molecular Structure
Psychotria / chemistry*

Substances

Alkaloids
Glycosides
Indole Alkaloids
psychollatine