We used an auditory-visual distraction task to investigate the functional relationship between distraction elicited by auditory novel events and a context of negative emotional processing, both at behavioural and electrophysiological (event-related brain potentials) levels in humans. Participants performed a decision task on pictures disclosing sceneries with a task-irrelevant emotional load or neutral, whereas ignoring sounds presented concomitantly. Our data showed that novel sounds yielded stronger behavioural disruption on participants' visual task performance in negative context compared to the neutral one. Accordingly, late novelty P3 responses to novel sounds were enhanced. These results demonstrate that the negative emotional context enhances the activation of neural networks in the auditory novelty system, enhancing auditory novelty processing under potentially threatening conditions.