Diagnosis and management of pleomorphic sarcomas (so-called "MFH") in adults

J Surg Oncol. 2008 Mar 15;97(4):330-9. doi: 10.1002/jso.20972.

Abstract

The existence of "malignant fibrous histiocytoma" ("MFH") as a distinct entity is controversial. Previously accepted as the most common sarcoma affecting adults, it is now known to comprise a heterogeneous group of tumors without a specific known line of differentiation. Reclassification of many tumors in this group afforded better prognostication, but traditional treatments still apply. Pleomorphic soft tissue tumors for which a line of differentiation is debatable are presently categorized as undifferentiated pleomorphic sarcoma.

Publication types

  • Review

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Histiocytoma, Malignant Fibrous / classification
  • Histiocytoma, Malignant Fibrous / diagnosis*
  • Histiocytoma, Malignant Fibrous / pathology
  • Histiocytoma, Malignant Fibrous / therapy*
  • Humans
  • Leiomyosarcoma / diagnosis
  • Leiomyosarcoma / therapy
  • Liposarcoma / diagnosis
  • Liposarcoma / therapy
  • Prognosis
  • Sarcoma / classification
  • Sarcoma / diagnosis*
  • Sarcoma / pathology
  • Sarcoma / therapy*