Progesterone receptor +331G/A polymorphism in endometriosis and deep-infiltrating endometriosis

Fertil Steril. 2008 Oct;90(4):1243-5. doi: 10.1016/j.fertnstert.2007.11.034. Epub 2008 Feb 20.

Abstract

In this study, we sought to examine the association between P receptor +331G/A polymorphism and endometriosis. We excluded any relationship between endometriosis in general and the P receptor +331G/A polymorphism but found a significant association with deep-infiltrating endometriosis, supporting a potential role of this variant in the P receptor-dependent invasive behavior of endometrial cells.

MeSH terms

  • Endometriosis / classification
  • Endometriosis / epidemiology*
  • Endometriosis / genetics*
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Heterozygote
  • Humans
  • Italy / epidemiology
  • Polymorphism, Single Nucleotide / genetics*
  • Prevalence
  • Receptors, Progesterone / genetics*
  • Risk Assessment / methods*
  • Risk Factors

Substances

  • Receptors, Progesterone