Pallbearer and friends: lending a hand in apoptotic cell clearance

Trends Cell Biol. 2008 Mar;18(3):95-7. doi: 10.1016/j.tcb.2007.12.005. Epub 2008 Feb 15.

Abstract

Engulfment and prompt removal of apoptotic cells occurs from embryogenesis throughout the lifespan of multicellular organisms. A new player, Pallbearer, has recently been identified in Drosophila as being important for efficient engulfment by macrophages. Pallbearer is a component of the SCF E3 ubiquitin ligase complex involved in the ubiquitylation of proteins targeted for proteasomal degradation. This work provides the first link between the cellular processes of ubiquitylation/proteasomal degradation and the ability to clear apoptotic cells efficiently.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis*
  • Drosophila Proteins / metabolism*
  • Humans
  • Macrophages / enzymology
  • Macrophages / metabolism*
  • Phagocytosis*
  • Proteasome Endopeptidase Complex / metabolism*
  • SKP Cullin F-Box Protein Ligases / metabolism*
  • Signal Transduction
  • Ubiquitin / metabolism*

Substances

  • Drosophila Proteins
  • Ubiquitin
  • SKP Cullin F-Box Protein Ligases
  • Proteasome Endopeptidase Complex