Abstract
PB183, a non-selective sigma receptor ligand displaying high sigma-1 and sigma-2 receptor affinity, was evaluated in prostate tumour cell lines for its suitability as PET radiotracer. The pharmacodynamic and pharmacokinetic properties suggested PB183 as a potential PET radiotracer to visualize prostate adenocarcinoma.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Adenocarcinoma / diagnostic imaging*
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Animals
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Cell Line, Tumor
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Chromatography, High Pressure Liquid
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Flow Cytometry
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Male
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Mice
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Mice, Transgenic
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Molecular Structure
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Naphthalenes* / chemistry
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Naphthalenes* / pharmacokinetics
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Piperazines* / chemistry
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Piperazines* / pharmacokinetics
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Positron-Emission Tomography*
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Prostatic Neoplasms / diagnostic imaging*
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Receptors, sigma / metabolism*
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Sigma-1 Receptor
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Naphthalenes
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PB183 compound
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Piperazines
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Receptors, sigma
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sigma-2 receptor