Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production

Clin Vaccine Immunol. 2008 Apr;15(4):720-5. doi: 10.1128/CVI.00224-07. Epub 2008 Feb 13.

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / immunology
  • B7-1 Antigen / biosynthesis
  • B7-1 Antigen / immunology
  • B7-2 Antigen / biosynthesis
  • B7-2 Antigen / immunology
  • Dendritic Cells / immunology*
  • Dendritic Cells / virology*
  • Histocompatibility Antigens Class II / immunology
  • Interleukin-10 / biosynthesis*
  • Interleukin-10 / immunology
  • Lymphocyte Activation
  • Porcine Reproductive and Respiratory Syndrome / immunology*
  • Porcine Reproductive and Respiratory Syndrome / virology
  • Porcine respiratory and reproductive syndrome virus / immunology*
  • Swine
  • T-Lymphocytes / immunology
  • Up-Regulation

Substances

  • B7-1 Antigen
  • B7-2 Antigen
  • Histocompatibility Antigens Class II
  • Interleukin-10