Neuromuscular painful disorders: a rare side effect of voriconazole in lung transplant patients under tacrolimus

V Boussaud; N Daudet; E M Billaud; A Lillo-Le Louet; P Chevalier; C Amrein; M Maud Bergé; R Guillemain; C Le Beller

doi:10.1016/j.healun.2007.09.022

Neuromuscular painful disorders: a rare side effect of voriconazole in lung transplant patients under tacrolimus

J Heart Lung Transplant. 2008 Feb;27(2):229-32. doi: 10.1016/j.healun.2007.09.022.

Authors

V Boussaud¹, N Daudet, E M Billaud, A Lillo-Le Louet, P Chevalier, C Amrein, M Maud Bergé, R Guillemain, C Le Beller

Affiliation

¹ Département de chirurgie cardio-vasculaire, Hôpital Européen Georges Pompidou, Paris, France.

PMID: 18267232
DOI: 10.1016/j.healun.2007.09.022

Abstract

Voriconazole is an anti-fungal agent active against Aspergillus infection that is used for prophylaxis and curative treatment in lung transplant patients. We present nine cases of painful neuromuscular disorders, an unusual and rare side effect of high-dose voriconazole in association with tacrolimus.

MeSH terms

Adolescent
Adult
Aspergillosis / drug therapy
Cohort Studies
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Interactions
Drug Therapy, Combination
Female
Follow-Up Studies
Graft Rejection / microbiology
Graft Rejection / prevention & control*
Humans
Lung Transplantation / adverse effects*
Lung Transplantation / methods
Male
Middle Aged
Neuromuscular Diseases / chemically induced*
Neuromuscular Diseases / physiopathology
Pain / chemically induced
Pain / physiopathology
Postoperative Complications / microbiology
Postoperative Complications / prevention & control
Pyrimidines / adverse effects*
Pyrimidines / therapeutic use
Retrospective Studies
Risk Assessment
Severity of Illness Index
Tacrolimus / therapeutic use*
Treatment Outcome
Triazoles / adverse effects*
Triazoles / therapeutic use
Voriconazole

Substances

Pyrimidines
Triazoles
Voriconazole
Tacrolimus