Primary synovial sarcoma arising in the parotid region diagnosed by fluorescence in situ hybridization

Auris Nasus Larynx. 2008 Dec;35(4):583-6. doi: 10.1016/j.anl.2007.12.003. Epub 2008 Feb 8.

Abstract

Synovial sarcomas account for 5% of pediatric soft tissue sarcomas, and primarily arise in the extremities. We report a case of synovial sarcoma in the parotid region. A 29-year-old woman presented with a 3-year history of a slow-growing, slight painful swelling in the preauricular region. The patient underwent right deep parotidectomy preserved with facial nerve. In immunohistochemistry, the epithelial cells were positive for cytokeratin AE1/3 and epithelial membrane antigen. The stromal cells were immunoreactive for vimentin and BCL2. The both types of cells were positive for CD99. The SYT-SSX fusion gene from chromosomal translocation was detected by fluorescence in situ hybridization in this case.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • In Situ Hybridization, Fluorescence*
  • Magnetic Resonance Imaging
  • Parotid Gland / pathology
  • Parotid Gland / surgery
  • Parotid Neoplasms / pathology*
  • Parotid Neoplasms / radiotherapy
  • Parotid Neoplasms / surgery
  • Proto-Oncogene Proteins / genetics
  • Radiotherapy, Adjuvant
  • Repressor Proteins / genetics
  • Sarcoma, Synovial / pathology*
  • Sarcoma, Synovial / radiotherapy
  • Sarcoma, Synovial / surgery

Substances

  • Biomarkers, Tumor
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • SS18 protein, human