Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

Charles-Gabin Mabiala-Bassiloua; Magdalena Zwolinska; Helene Therisod; Jurgen Sygusch; Michel Therisod

doi:10.1016/j.bmcl.2008.01.076

Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1735-7. doi: 10.1016/j.bmcl.2008.01.076. Epub 2008 Jan 26.

Authors

Charles-Gabin Mabiala-Bassiloua¹, Magdalena Zwolinska, Helene Therisod, Jurgen Sygusch, Michel Therisod

Affiliation

¹ ECBB, ICMMO, Univ Paris-Sud, UMR 8182, F-91405 Orsay, France.

PMID: 18261903
DOI: 10.1016/j.bmcl.2008.01.076

Abstract

We report the first unambiguous syntheses of glucitol-1,6-bis-phosphate and mannitol-1,6-bis-phosphate and their competitive inhibition of various fructose bis-phosphate aldolases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Fructose-Bisphosphate Aldolase / antagonists & inhibitors*
Helicobacter pylori / enzymology
Mannitol Phosphates / chemical synthesis*
Mannitol Phosphates / pharmacology
Molecular Structure
Saccharomyces cerevisiae / enzymology
Sorbitol / analogs & derivatives*
Sorbitol / chemical synthesis*
Sorbitol / pharmacology
Sugar Phosphates / chemical synthesis*
Sugar Phosphates / pharmacology

Substances

Anti-Bacterial Agents
Mannitol Phosphates
Sugar Phosphates
glucitol-1,6-bis-phosphate
mannitol-1,6-bis-phosphate
Sorbitol
Fructose-Bisphosphate Aldolase