Abnormalities in glucose metabolism in patients with schizophrenia treated with atypical antipsychotic medications

Am J Med. 2008 Feb;121(2):98-104. doi: 10.1016/j.amjmed.2007.08.036.

Abstract

The incidence of carbohydrate intolerance and overt diabetes is increased in patients with schizophrenia treated with the newer atypical antipsychotic agents. The precise mechanism for these abnormalities remains obscure. This review examines the potential interaction between atypical antipsychotic medications and several hormones known to influence appetite regulation and carbohydrate metabolism.

Publication types

  • Review

MeSH terms

  • Animals
  • Antipsychotic Agents / adverse effects*
  • Cannabinoid Receptor Modulators / metabolism
  • Diabetes Mellitus / chemically induced
  • Diabetes Mellitus / metabolism
  • Ghrelin / drug effects
  • Ghrelin / metabolism
  • Glucagon / drug effects
  • Glucagon / metabolism
  • Glucose Metabolism Disorders / chemically induced*
  • Glucose Metabolism Disorders / metabolism
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Leptin / metabolism
  • Schizophrenia / drug therapy*

Substances

  • Antipsychotic Agents
  • Cannabinoid Receptor Modulators
  • Ghrelin
  • Insulin
  • Leptin
  • Glucagon