By using landscape analyzing software Fragstats 3.3 and the interpretation results of remote-sensing images of 1960, 1975, 1987, 1995, 2000 and 2005, this paper analyzed the dynamic changes of landscape pattern during the desertification in Duolun County of Inner Mongolia in 1960-2005. The results showed that in 1960-1995, the desertification area appeared a tendency of increasing first and decreasing then, with a total increase of 212.7 km2. The numbers of desertification landscape patches decreased after an initial increase, landscape diversity and evenness increased, and the shapes of light-, moderate-, and heavy desertification patches tended to be simplex. From 1995 to 2005, the numbers of desertification patches increased greatly, landscape diversity and evenness decreased, and the shapes of light-, moderate-, and heavy desertification patches tended to be complex. Since 1960, the shapes of severe desertification patches had been inclined to complication. In the study period, the whole desertification landscape showed a trend of integrity-broken-integrity-broken, and the broken degree of the patch types of desertification landscape was gradually from light down to severe.