Abstract
Three lipopeptides, ciliatamides A-C ( 1- 3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A ( 1) and B ( 2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification*
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Antiprotozoal Agents / pharmacology*
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Leishmania / drug effects*
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Lipopeptides
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Lipoproteins / chemistry
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Lipoproteins / isolation & purification*
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Lipoproteins / pharmacology*
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Molecular Structure
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Oceans and Seas
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Oligopeptides / chemistry
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Oligopeptides / isolation & purification*
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Oligopeptides / pharmacology*
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Porifera / chemistry*
Substances
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Antineoplastic Agents
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Antiprotozoal Agents
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Lipopeptides
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Lipoproteins
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Oligopeptides
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ciliatamide A
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ciliatamide B
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ciliatamide C