[Effect of baicalin on in vivo anti-virus]

Zhongguo Zhong Yao Za Zhi. 2007 Nov;32(22):2413-5.
[Article in Chinese]

Abstract

Objective: This study is about the in vivo antivirus effect of baicalin.

Method: Adopting in vivo experiment, we administered one group of mice 2 days before infected with influenza virus (A/FM/1/47) , while administer the other group with baicalin one day after infected, to observe the effect of baicalin in protecting and curing mice against influenza virus.

Result: Baicalin can obviously prolong the survival time of mice infected with influenza virus (A/FM/1/47) (P <0.01), eliminate the influenza virus in lung, reduce the hemagglutination tite and infectivity in pulmo, and reverse mice's pneumonic pathological changes.

Conclusion: Baicalin can obviously counteract influenza virus.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / therapeutic use*
  • Female
  • Flavonoids / isolation & purification
  • Flavonoids / therapeutic use*
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Lung / drug effects
  • Lung / pathology
  • Lung / virology
  • Male
  • Mice
  • Orthomyxoviridae Infections / drug therapy*
  • Orthomyxoviridae Infections / virology
  • Phytotherapy
  • Plants, Medicinal / chemistry
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / virology
  • Random Allocation
  • Scutellaria baicalensis / chemistry
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Flavonoids
  • baicalin