Immunopharmacological properties of noopept

L P Kovalenko; E V Shipaeva; S V Alekseeva; A V Pronin; A D Durnev; T A Gudasheva; R U Ostrovskaja; S B Seredenin

doi:10.1007/s10517-007-0251-3

Immunopharmacological properties of noopept

Bull Exp Biol Med. 2007 Jul;144(1):49-52. doi: 10.1007/s10517-007-0251-3.

[Article in English, Russian]

Authors

L P Kovalenko¹, E V Shipaeva, S V Alekseeva, A V Pronin, A D Durnev, T A Gudasheva, R U Ostrovskaja, S B Seredenin

Affiliation

¹ V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.

PMID: 18256750
DOI: 10.1007/s10517-007-0251-3

Abstract

Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, noopept exhibited immunocorrector properties.

MeSH terms

Administration, Oral
Animals
Anti-Inflammatory Agents / therapeutic use
Antibody Formation / drug effects
Dipeptides / administration & dosage
Dipeptides / immunology
Dipeptides / pharmacology*
Hypersensitivity, Delayed / drug therapy
Immunity, Cellular / drug effects
Injections, Intramuscular
Injections, Intraperitoneal
Injections, Intravenous
Injections, Subcutaneous
Macrophages, Peritoneal / immunology
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Phagocytosis / drug effects
Sheep

Substances

Anti-Inflammatory Agents
Dipeptides
ethyl phenylacetyl-Pro-Gly