Apoptosis of leukocytes as a marker of neutrophil-endotheliocyte interaction in coronary heart disease

A B Salmina; V A Shul'man; S Yu Nikulina; L V Trufanova; A A Fursov; P A But'yanov; A P Kuskaev; E V Bol'shakova; M Yu Kotlovskii

doi:10.1007/s10517-007-0248-y

Apoptosis of leukocytes as a marker of neutrophil-endotheliocyte interaction in coronary heart disease

Bull Exp Biol Med. 2007 Jul;144(1):39-41. doi: 10.1007/s10517-007-0248-y.

[Article in English, Russian]

Authors

A B Salmina¹, V A Shul'man, S Yu Nikulina, L V Trufanova, A A Fursov, P A But'yanov, A P Kuskaev, E V Bol'shakova, M Yu Kotlovskii

Affiliation

¹ Department of Biochemistry with a Course of Medical Chemistry, Krasnoyarsk State Medical Academy, Federal Agency for Health Care and Social Development.

PMID: 18256747
DOI: 10.1007/s10517-007-0248-y

Abstract

We studied the mechanism of interaction of peripheral blood neutrophils with endothelial cells (expression of cell adhesion molecules and production of NO) and the role of neutrophil apoptosis in the development of endothelial dysfunction. The effects of mitochondrial dysfunction of neutrophils on the development of apoptosis of these cells after their interaction with endothelial cells were analyzed.

MeSH terms

Apoptosis*
Cell Communication / physiology*
Coronary Disease / blood*
Coronary Disease / physiopathology
Endothelial Cells / physiology*
Humans
Leukocytes / cytology*
Male
Middle Aged
Neutrophils / physiology*
Nitric Oxide / blood*
Platelet Endothelial Cell Adhesion Molecule-1 / biosynthesis

Substances

Platelet Endothelial Cell Adhesion Molecule-1
Nitric Oxide