Abstract
Proton pump inhibitors (PPIs) are commonly used drugs, several of which are available without a prescription. Two recent studies have demonstrated increased hip fracture rates associated with PPI use. Theoretically, PPIs could impair intestinal calcium absorption resulting in increased rates of bone loss and a greater risk of fragility fracture.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Bone Density / drug effects*
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Bone Resorption
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Bone and Bones / drug effects*
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Bone and Bones / metabolism*
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Calcium / metabolism*
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Fractures, Bone / chemically induced
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Fractures, Bone / epidemiology
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Hip Fractures / chemically induced
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Hip Fractures / epidemiology
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Humans
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Proton Pump Inhibitors / adverse effects*
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Proton Pump Inhibitors / therapeutic use
Substances
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Proton Pump Inhibitors
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Calcium