Abstract
Doripenem, a parenteral carbapenem, exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and PBP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death. This PBP affinity profile correlates with the broad-spectrum gram-negative activity observed with doripenem.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / metabolism*
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / metabolism
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Carbapenems / metabolism*
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Carbapenems / pharmacology
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Doripenem
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Escherichia coli / drug effects
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Escherichia coli / metabolism*
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Escherichia coli Proteins / metabolism
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Humans
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Penicillin-Binding Proteins / metabolism*
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / metabolism*
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beta-Lactams / metabolism*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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Escherichia coli Proteins
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Penicillin-Binding Proteins
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beta-Lactams
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Doripenem