Multiple Endocrine Neoplasia type 1

Eur J Intern Med. 2008 Mar;19(2):99-103. doi: 10.1016/j.ejim.2007.08.004. Epub 2007 Nov 7.

Abstract

The co-occurrence of parathyroid hyperplasia with pancreatic endocrine tumours and/or pituitary adenoma is classified as Multiple Endocrine Neoplasia type 1 (MEN-1) and is caused by a germ-line mutation in MEN-1 gene encoding a tumour suppressor protein, menin. This review presents clinical expressions, diagnosis and management of the MEN-1 syndrome. Properties and mechanisms of menin functions are also reviewed.

Publication types

  • Review

MeSH terms

  • Gastrinoma / diagnosis
  • Gastrinoma / genetics
  • Gene Expression
  • Humans
  • Hyperparathyroidism / diagnosis
  • Hyperparathyroidism / genetics
  • Insulinoma / diagnosis
  • Insulinoma / genetics
  • Multiple Endocrine Neoplasia Type 1 / diagnosis
  • Multiple Endocrine Neoplasia Type 1 / genetics*
  • Multiple Endocrine Neoplasia Type 1 / therapy
  • Mutation
  • Prolactinoma / diagnosis
  • Prolactinoma / genetics
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*

Substances

  • MEN1 protein, human
  • Proto-Oncogene Proteins