A homemade high-resolution orthogonal-injection time-of-flight mass spectrometer with a heated capillary inlet

Rev Sci Instrum. 2008 Jan;79(1):013109. doi: 10.1063/1.2832334.

Abstract

We describe a homemade high-resolution orthogonal-injection time-of-flight (O-TOF) mass spectrometer combing a heated capillary inlet. The O-TOF uses a heated capillary tube combined with a radio-frequency only quadrupole (rf-only quadrupole) as an interface to help the ion transmission from the atmospheric pressure to the low-pressure regions. The principle, configuration of the O-TOF, and the performance of the instrument are introduced in this paper. With electrospray ion source, the performances of the mass resolution, the sensitivity, the mass range, and the mass accuracy are described. We also include our results obtained by coupling atmospheric pressure matrix-assisted laser deporption ionization with this instrument.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capillary Action
  • Equipment Design
  • Equipment Failure Analysis
  • Heating / instrumentation*
  • Microfluidics / instrumentation*
  • Microfluidics / methods
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Specimen Handling / instrumentation*
  • Specimen Handling / methods
  • Spectrometry, Mass, Electrospray Ionization / instrumentation*
  • Spectrometry, Mass, Electrospray Ionization / methods
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation*