Linking differential chromatin loops to transcriptional decisions

Mol Cell. 2008 Feb 1;29(2):154-6. doi: 10.1016/j.molcel.2008.01.008.

Abstract

GATA-1 and GATA-2 control proliferation and differentiation of hematopoietic progenitor cells via transcriptional regulation. In this issue of Molecular Cell, Jing et al. (2008) demonstrate that GATA factor exchange on the Kit locus directs a transcriptional switch by reconfiguring chromatin loops.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Line
  • Chromatin / genetics
  • Chromatin / metabolism
  • Chromatin Assembly and Disassembly / physiology*
  • Enhancer Elements, Genetic / physiology
  • Erythropoiesis / physiology*
  • GATA1 Transcription Factor / genetics
  • GATA1 Transcription Factor / metabolism*
  • GATA2 Transcription Factor / genetics
  • GATA2 Transcription Factor / metabolism*
  • Gene Silencing / physiology*
  • Mice
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Proto-Oncogene Proteins c-kit / biosynthesis*
  • Proto-Oncogene Proteins c-kit / genetics
  • Quantitative Trait Loci / physiology*
  • Response Elements / physiology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • GATA1 Transcription Factor
  • GATA2 Transcription Factor
  • Gata1 protein, mouse
  • Gata2 protein, mouse
  • Nuclear Proteins
  • Transcription Factors
  • Zfpm1 protein, mouse
  • Proto-Oncogene Proteins c-kit