Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test

J Neural Transm (Vienna). 2008 Jun;115(6):829-30. doi: 10.1007/s00702-008-0023-x. Epub 2008 Feb 1.

Abstract

The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.

MeSH terms

  • 8-Bromo Cyclic Adenosine Monophosphate / pharmacology*
  • Animals
  • Antidepressive Agents / pharmacology*
  • Brain / drug effects*
  • Brain / enzymology
  • Brain / physiopathology
  • Cyclic AMP / analogs & derivatives
  • Cyclic AMP / pharmacology
  • Cyclic AMP-Dependent Protein Kinases / drug effects
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / enzymology
  • Depressive Disorder / physiopathology
  • Dose-Response Relationship, Drug
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / pharmacology
  • Motor Activity / drug effects
  • Phosphorylation / drug effects
  • Rats
  • Reaction Time / drug effects
  • Stress, Psychological / drug therapy*
  • Stress, Psychological / enzymology
  • Stress, Psychological / physiopathology
  • Swimming
  • Thionucleotides / pharmacology

Substances

  • Antidepressive Agents
  • Enzyme Inhibitors
  • Thionucleotides
  • 8-Bromo Cyclic Adenosine Monophosphate
  • adenosine-3',5'-cyclic phosphorothioate
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases