Abstract
The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.
MeSH terms
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8-Bromo Cyclic Adenosine Monophosphate / pharmacology*
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Animals
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Antidepressive Agents / pharmacology*
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Brain / drug effects*
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Brain / enzymology
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Brain / physiopathology
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Cyclic AMP / analogs & derivatives
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Cyclic AMP / pharmacology
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Cyclic AMP-Dependent Protein Kinases / drug effects
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Depressive Disorder / drug therapy*
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Depressive Disorder / enzymology
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Depressive Disorder / physiopathology
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Dose-Response Relationship, Drug
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Enzyme Activation / drug effects
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Enzyme Inhibitors / pharmacology
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Motor Activity / drug effects
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Phosphorylation / drug effects
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Rats
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Reaction Time / drug effects
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Stress, Psychological / drug therapy*
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Stress, Psychological / enzymology
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Stress, Psychological / physiopathology
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Swimming
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Thionucleotides / pharmacology
Substances
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Antidepressive Agents
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Enzyme Inhibitors
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Thionucleotides
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8-Bromo Cyclic Adenosine Monophosphate
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adenosine-3',5'-cyclic phosphorothioate
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases