Further cytotoxic sesquiterpene lactones from Elephantopus mollis KUNTH

Chem Pharm Bull (Tokyo). 2008 Feb;56(2):231-3. doi: 10.1248/cpb.56.231.

Abstract

Three new sesquiterpene lactones, (4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide (1), (4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide (2) and 2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide (3), have been isolated from roots and stems of Elephantopus mollis together with two known sesquiterpene lactones (4, 5). The identification of the isolates was accomplished by spectroscopic methods. Compounds (1-5) exhibited significant cytotoxic activities against mouse neuroblastoma B104 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Asteraceae / chemistry*
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / pathology
  • Cell Line, Tumor
  • Chromatography, Thin Layer
  • Coloring Agents
  • Drug Screening Assays, Antitumor
  • Lactones / isolation & purification*
  • Lactones / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mice
  • Neuroblastoma / drug therapy
  • Neuroblastoma / pathology
  • Plant Roots / chemistry
  • Plant Stems / chemistry
  • Rhodamines
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared

Substances

  • (4betaH)-5alpha-hydroxy-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(10),11(13)-guaiadien-12,6alpha-olide
  • (4betaH)-8alpha-(2-methylbut-2-enoyloxy)-2-oxo-1(5),10(14),11(13)-guaiatrien-12,6alpha-olide
  • 2,5-epoxy-2beta-hydroxy-4alpha-methoxy-8alpha-(2-methylbut-2-enoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide
  • Antineoplastic Agents, Phytogenic
  • Coloring Agents
  • Lactones
  • Rhodamines
  • Sesquiterpenes
  • lissamine rhodamine B