Phellifuropyranone A: a new furopyranone compound isolated from fruit bodies of wild Phellinus linteus

Kazuo Kojima; Takamasa Ohno; Makoto Inoue; Hajime Mizukami; Akito Nagatsu

doi:10.1248/cpb.56.173

Phellifuropyranone A: a new furopyranone compound isolated from fruit bodies of wild Phellinus linteus

Chem Pharm Bull (Tokyo). 2008 Feb;56(2):173-5. doi: 10.1248/cpb.56.173.

Authors

Kazuo Kojima¹, Takamasa Ohno, Makoto Inoue, Hajime Mizukami, Akito Nagatsu

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Japan.

PMID: 18239302
DOI: 10.1248/cpb.56.173

Abstract

A new furopyranone, phellifuropyranone A, was isolated from fruit bodies of wild Phellinus linteus as well as phelligridin G, and their chemical structures were determined by various spectroscopic methods including measurement of NMR spectra. Phellifuropyranone A together with meshimakobnol A and meshimakobnol B showed antiproliferative activity against mouse melanoma cells and human lung cancer cells in vitro.

MeSH terms

Animals
Antibiotics, Antineoplastic / isolation & purification
Antibiotics, Antineoplastic / pharmacology*
Basidiomycota / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Fruiting Bodies, Fungal / chemistry*
Humans
Magnetic Resonance Spectroscopy
Mice
Pyrones / isolation & purification
Pyrones / pharmacology*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Antibiotics, Antineoplastic
Pyrones
phellifuropyranone A