Cyclic GMP/protein kinase G phosphorylation of Smad3 blocks transforming growth factor-beta-induced nuclear Smad translocation: a key antifibrogenic mechanism of atrial natriuretic peptide

Circ Res. 2008 Feb 1;102(2):151-3. doi: 10.1161/CIRCRESAHA.107.170217.
No abstract available

Publication types

  • Comment
  • Editorial
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Atrial Natriuretic Factor / physiology*
  • Cyclic GMP
  • Cyclic GMP-Dependent Protein Kinases / metabolism*
  • Heart Diseases / pathology
  • Humans
  • Signal Transduction
  • Smad3 Protein / metabolism*
  • Transforming Growth Factor beta / physiology*

Substances

  • Smad3 Protein
  • Transforming Growth Factor beta
  • Atrial Natriuretic Factor
  • Cyclic GMP-Dependent Protein Kinases
  • Cyclic GMP