Bioabsorbable interference screws have replaced metal interference screws in anterior cruciate ligament reconstruction surgery because they have several advantages. Poly-L-lactide (PLLA) is one of the commonly used materials for bioabsorbable interference screws. PLLA produces a lower inflammatory reaction than polyglycolide as a result of its slower degradation rate and better biocompatibility. We describe a case of a delayed intra-articular inflammatory reaction caused by a PLLA bioabsorbable interference screw used in anterior cruciate ligament reconstruction.