One-pot catalytic asymmetric cascade synthesis of cycloheptane derivatives

Chemistry. 2008;14(9):2693-8. doi: 10.1002/chem.200701918.

Abstract

A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiral-amine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (>25:1 d.r. and 98- >99 ee).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Crystallography, X-Ray
  • Cyclization
  • Cycloheptanes / chemical synthesis*
  • Cycloheptanes / chemistry
  • Magnetic Resonance Spectroscopy / methods
  • Magnetic Resonance Spectroscopy / standards
  • Models, Molecular
  • Molecular Structure
  • Reference Standards
  • Stereoisomerism

Substances

  • Cycloheptanes