Abstract
Intraperitoneal injection of rat IFN-alpha and human IL-2 to rats with experimental endometriosis led to complete regression of endometrioid heterotopies in 50 and 60% cases, respectively. Retention of the endometrioid epithelium resulted in a significant reduction of proliferative activity of its cells, degree of vascularization, and number of macrophages in the leukocytic infiltration of endometrioid heterotopies.
MeSH terms
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Animals
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Cell Proliferation / drug effects
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Endometriosis / drug therapy*
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Endometriosis / pathology
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Endometrium / blood supply
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Endometrium / drug effects
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Endometrium / pathology
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Female
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Humans
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Immunologic Factors / administration & dosage
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Injections, Intraperitoneal
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Interferon Type I / administration & dosage*
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Interleukin-2 / administration & dosage*
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Leukocytes / drug effects
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Leukocytes / pathology
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Rats
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Rats, Wistar
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Recombinant Proteins / administration & dosage
Substances
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IL2 protein, human
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Immunologic Factors
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Interferon Type I
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Interleukin-2
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Recombinant Proteins