Comparative efficiency of intraperitoneal interleukine-2 and interferon-A in rats with experimental endometriosis

Bull Exp Biol Med. 2007 Mar;143(3):363-7. doi: 10.1007/s10517-007-0113-z.

Abstract

Intraperitoneal injection of rat IFN-alpha and human IL-2 to rats with experimental endometriosis led to complete regression of endometrioid heterotopies in 50 and 60% cases, respectively. Retention of the endometrioid epithelium resulted in a significant reduction of proliferative activity of its cells, degree of vascularization, and number of macrophages in the leukocytic infiltration of endometrioid heterotopies.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cell Proliferation / drug effects
  • Endometriosis / drug therapy*
  • Endometriosis / pathology
  • Endometrium / blood supply
  • Endometrium / drug effects
  • Endometrium / pathology
  • Female
  • Humans
  • Immunologic Factors / administration & dosage
  • Injections, Intraperitoneal
  • Interferon Type I / administration & dosage*
  • Interleukin-2 / administration & dosage*
  • Leukocytes / drug effects
  • Leukocytes / pathology
  • Rats
  • Rats, Wistar
  • Recombinant Proteins / administration & dosage

Substances

  • IL2 protein, human
  • Immunologic Factors
  • Interferon Type I
  • Interleukin-2
  • Recombinant Proteins