Study of hypoxia-induced expression of HIF-1alpha in retina pigment epithelium

Bull Exp Biol Med. 2007 Mar;143(3):323-7. doi: 10.1007/s10517-007-0101-3.

Abstract

It was shown that the expression of HIF-1alpha in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1alpha reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1alpha decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1alpha in RPE. It can be an important step in choriodal neovascularization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / genetics
  • Actins / metabolism
  • Adult
  • Base Sequence
  • Choroidal Neovascularization / etiology
  • DNA Primers / genetics
  • Gene Expression
  • Humans
  • Hypoxia / complications
  • Hypoxia / genetics
  • Hypoxia / metabolism*
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • In Vitro Techniques
  • Male
  • Pigment Epithelium of Eye / metabolism*

Substances

  • Actins
  • DNA Primers
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit