Abstract
It was shown that the expression of HIF-1alpha in retinal pigment epithelium increased under hypoxic conditions. Eight hours after the start of hypoxic exposure, the expression of HIF-1alpha reached the peak and sustained after 24-hour hypoxia. However, the morphology of PRE cells began to change and the expression of HIF-1alpha decreased after long-term (48-hour) hypoxia. Hypoxia-induced increase in the level of HIF-1alpha in RPE. It can be an important step in choriodal neovascularization.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Actins / genetics
-
Actins / metabolism
-
Adult
-
Base Sequence
-
Choroidal Neovascularization / etiology
-
DNA Primers / genetics
-
Gene Expression
-
Humans
-
Hypoxia / complications
-
Hypoxia / genetics
-
Hypoxia / metabolism*
-
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
-
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
-
In Vitro Techniques
-
Male
-
Pigment Epithelium of Eye / metabolism*
Substances
-
Actins
-
DNA Primers
-
HIF1A protein, human
-
Hypoxia-Inducible Factor 1, alpha Subunit