Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata

Malcolm S Buchanan; Anthony R Carroll; Annette Edser; Melissa Sykes; Gregory A Fechner; Paul I Forster; Gordon P Guymer; Ronald J Quinn

doi:10.1016/j.bmcl.2007.12.060

Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1495-7. doi: 10.1016/j.bmcl.2007.12.060. Epub 2007 Dec 25.

Authors

Malcolm S Buchanan¹, Anthony R Carroll, Annette Edser, Melissa Sykes, Gregory A Fechner, Paul I Forster, Gordon P Guymer, Ronald J Quinn

Affiliation

¹ Eskitis Institute, Griffith University, Brisbane, Qld 4111, Australia.

PMID: 18222087
DOI: 10.1016/j.bmcl.2007.12.060

Abstract

A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arginine / analogs & derivatives*
Carboxypeptidase B / antagonists & inhibitors*
Guanidines / chemistry*
Guanidines / isolation & purification
Guanidines / pharmacology*
Loranthaceae / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Protease Inhibitors / chemistry*
Protease Inhibitors / isolation & purification
Protease Inhibitors / pharmacology*
Succinates / chemistry*
Succinates / isolation & purification
Succinates / pharmacology*

Substances

Guanidines
Plant Extracts
Protease Inhibitors
Succinates
lysianadioic acid
Arginine
Carboxypeptidase B