Abstract
We herein report a case of long-term surviving patient who was treated with intravenous administration of activated autologous lymphocytes and low-dose chemotherapy. The patient was an 82-year-old female. She underwent radical resection for sigmoid colon cancer in 1998 and right lobectomy of the liver for metastatic liver tumor in 2001. A follow up CT revealed the metastasis to the bilateral lung on November 2003. Then she received a treatment with UFT plus low-dose CPT-11/CDDP and activated autologous lymphocytes. Although the response of the treatment was SD, the serum CEA level decreased to a normal range. The treatment continued with delayed administration for 30 months while CEA and the size of the tumors increased very slowly. After that, her treatment was changed with a single administration of S-1. She obtained a 3.5 year survival with an inhibition of fast tumor growth by chemo-immunotherapy.
MeSH terms
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols* / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols* / therapeutic use
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Camptothecin / administration & dosage
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Camptothecin / analogs & derivatives
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Camptothecin / therapeutic use
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Cisplatin / administration & dosage
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Cisplatin / therapeutic use
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Drug Combinations
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Female
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Humans
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Immunotherapy*
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Injections, Intravenous
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Irinotecan
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Lung Neoplasms / immunology*
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Lung Neoplasms / pathology
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Lung Neoplasms / secondary
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Lung Neoplasms / therapy*
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Lymphocyte Activation
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Lymphocyte Transfusion*
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Lymphocytes / immunology*
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Oxonic Acid / administration & dosage
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Oxonic Acid / therapeutic use
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Sigmoid Neoplasms / pathology*
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Sigmoid Neoplasms / surgery
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Tegafur / administration & dosage
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Tegafur / therapeutic use
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Time Factors
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Tomography, X-Ray Computed
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Transplantation, Autologous
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Uracil / administration & dosage
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Uracil / therapeutic use
Substances
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Drug Combinations
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S 1 (combination)
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Tegafur
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Uracil
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Oxonic Acid
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Irinotecan
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Cisplatin
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Camptothecin