Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives

Sushma Manda; Ikuo Nakanishi; Kei Ohkubo; Yoshihiro Uto; Tomonori Kawashima; Hitoshi Hori; Kiyoshi Fukuhara; Haruhiro Okuda; Toshihiko Ozawa; Nobuo Ikota; Shunichi Fukuzumi; Kazunori Anzai

doi:10.1039/b715973k

Enhanced radical-scavenging activity of naturally-oriented artepillin C derivatives

Chem Commun (Camb). 2008 Feb 7:(5):626-8. doi: 10.1039/b715973k. Epub 2007 Nov 28.

Authors

Sushma Manda¹, Ikuo Nakanishi, Kei Ohkubo, Yoshihiro Uto, Tomonori Kawashima, Hitoshi Hori, Kiyoshi Fukuhara, Haruhiro Okuda, Toshihiko Ozawa, Nobuo Ikota, Shunichi Fukuzumi, Kazunori Anzai

Affiliation

¹ Radiation Modifier Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555, Japan.

PMID: 18209811
DOI: 10.1039/b715973k

Abstract

More than two-fold augmentation in the radical-scavenging activity of artepillin C could be achieved via altering the O-H bond dissociation enthalpy of artepillin C by means of structural modifications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzene Derivatives / chemistry
Free Radical Scavengers / chemistry*
Free Radical Scavengers / radiation effects
Molecular Structure
Peroxides / chemistry
Peroxides / radiation effects
Phenylpropionates / chemistry*
Phenylpropionates / radiation effects
Photochemistry
Stereoisomerism
Thermodynamics
Time Factors

Substances

Benzene Derivatives
Free Radical Scavengers
Peroxides
Phenylpropionates
artepillin C
cumene hydroperoxide