Electromagnetic interventions in general and those considering the musculoskeletal system in particular hold many obscurities. Several studies revealing positive effects of electromagnetic fields oppose those showing no beneficial effects. After a historical review and a discussion of basic details on electromagnetic signals, this article provides information on the effects of electromagnetic fields on a cellular level and gives an account of preclinical and clinical studies focused on electromagnetic interventions by means of weak pulsed electromagnetic fields on musculoskeletal disorders.