Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1

Angew Chem Int Ed Engl. 2008;47(8):1515-8. doi: 10.1002/anie.200702055.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cell Line
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases / antagonists & inhibitors*
  • DNA (Cytosine-5-)-Methyltransferases / metabolism*
  • DNA / chemical synthesis*
  • DNA / chemistry
  • DNA / pharmacology*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Mice
  • Myoblasts / drug effects
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Enzyme Inhibitors
  • DNA
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases
  • DNMT1 protein, human
  • Dnmt1 protein, mouse