Abstract
The humoral responses to recombinant MPT-51 and GlcB was determined by using an enzyme-linked immunosorbent assay. Levels of immunoglobulin M (IgM) against MPT-51 and IgG against GlcB were higher among tuberculosis (TB) patients than among control individuals. When the MPT-51 and GlcB assays were combined, 90.8% specificity and 75.5% sensitivity were observed. MPT-51 and GlcB were recognized in the humoral responses of Brazilian TB patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antibodies, Bacterial / blood*
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology*
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Bacterial Proteins / genetics
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Bacterial Proteins / immunology*
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Brazil
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Immunoglobulin G / blood
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Immunoglobulin M / blood
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Malate Synthase / genetics
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Malate Synthase / immunology*
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Male
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Middle Aged
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Mycobacterium tuberculosis / immunology*
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Recombinant Proteins / genetics
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Recombinant Proteins / immunology
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Sensitivity and Specificity
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Tuberculosis / immunology*
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Proteins
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Immunoglobulin G
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Immunoglobulin M
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MPT51 protein, Mycobacterium
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Recombinant Proteins
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Malate Synthase