Stereoselective one-pot, three-component synthesis of 4-amidotetrahydropyran

U C Reddy; B Rama Raju; E K Pramod Kumar; Anil K Saikia

doi:10.1021/jo7023366

Stereoselective one-pot, three-component synthesis of 4-amidotetrahydropyran

J Org Chem. 2008 Feb 15;73(4):1628-30. doi: 10.1021/jo7023366. Epub 2008 Jan 17.

Authors

U C Reddy¹, B Rama Raju, E K Pramod Kumar, Anil K Saikia

Affiliation

¹ Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.

PMID: 18198890
DOI: 10.1021/jo7023366

Abstract

The reaction of aldehyde with allylsilane in acetonitrile mediated by boron trifluoride etherate generated 4-aminotetrahydropyrans in good yields. The product is highly stereoselective.