Abstract
A methanol extract of the dried bark of Liriosma ovata afforded two new isoprenoid glycosides, a eudesmane sesquiterpene, 1alpha(beta- d-glucopyranosyloxy)eudesma-3alpha,4beta, 11-triol ( 1), and a C 13-norisoprenoid, 3alpha,6alpha-dihydroxymegastigman-7-en-9-one 3- O-beta- d-apiofuranosyl-(1-->6)-beta- d-glucopyranoside ( 2), as well as a known constituent, isopropyl-beta- d-apiofuranosyl-(1-->6)-beta- d-glucopyranoside ( 3). The structures of 1 and 2 were determined using spectroscopic methods. The methanol extract had a significant topical anti-inflammatory activity (ID 50, dose inducing 50% edema inhibition = 780 microg/cm (2)) about 8 times less than that of indomethacin (ID 50, 93 microg/cm (2)) assayed by the croton oil ear test in mice. In addition, the chloroform extract and compounds 1 and 2 showed weak antimicrobial activity against S taphylococcus aureus (MIC = 5.1, 2.1, and 4.0 mg/mL, respectively) using a broth microdilution assay.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Croton Oil / pharmacology
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Ear, External / drug effects
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Edema / drug therapy
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Inhibitory Concentration 50
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Italy
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Norisoprenoids / chemistry
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Norisoprenoids / isolation & purification*
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Norisoprenoids / pharmacology*
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Olacaceae / chemistry*
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Plant Bark / chemistry
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Sesquiterpenes
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Sesquiterpenes, Eudesmane / chemistry
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Sesquiterpenes, Eudesmane / isolation & purification*
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Sesquiterpenes, Eudesmane / pharmacology*
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Staphylococcus aureus / drug effects
Substances
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1alpha(beta-D-glucopyranosyloxy)eudesma-3alpha,4beta,11-triol
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Anti-Inflammatory Agents, Non-Steroidal
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C13-norisoprenoid, 3alpha,6alpha-dihydroxymegastigman-7-en-9-one 3- O-beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside
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Glucosides
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Norisoprenoids
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Sesquiterpenes
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Sesquiterpenes, Eudesmane
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isopropyl-beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside
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Croton Oil