Abstract
Imipenem distribution was characterized by microdialysis in the peritoneal fluid of rats with experimental pancreatitis. The ratios of peritoneal fluid to blood area under unbound concentration-versus-time curves were close to unity, suggesting that imipenem was not degraded in peritoneal fluid.
MeSH terms
-
Acute Disease
-
Animals
-
Anti-Bacterial Agents / administration & dosage
-
Anti-Bacterial Agents / pharmacokinetics*
-
Area Under Curve
-
Ascitic Fluid / chemistry
-
Ascitic Fluid / metabolism*
-
Imipenem / administration & dosage
-
Imipenem / pharmacokinetics*
-
Injections, Intravenous
-
Male
-
Microdialysis*
-
Pancreatitis / drug therapy*
-
Rats
-
Rats, Sprague-Dawley
Substances
-
Anti-Bacterial Agents
-
Imipenem