Abstract
The expression of a subset of Shigella flexneri virulence genes is dependent upon a cytoplasmic chaperone, IpgC, and an activator from the AraC/XylS family, MxiE. In this paper, we report that the chaperone forms a specific and stable heteromer with MxiE.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Dimerization
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Gene Expression Regulation, Bacterial
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Molecular Chaperones / chemistry
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Molecular Chaperones / genetics
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Molecular Chaperones / metabolism*
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Protein Binding
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Shigella flexneri / genetics
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Shigella flexneri / metabolism*
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Shigella flexneri / pathogenicity
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Transcription Factors / chemistry
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Virulence / genetics
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Molecular Chaperones
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MxiE protein, Shigella flexneri
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Transcription Factors
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IpgC protein, Shigella