Abstract
Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae flatten and caveolin-1 is released into the cell membrane, where it is rapidly internalized and degraded.
MeSH terms
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Animals
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Caveolae / metabolism*
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Caveolae / ultrastructure
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Caveolin 1 / metabolism
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Cell Membrane / metabolism*
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Cell Membrane / ultrastructure
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Endocytosis / physiology
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Humans
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Insulin / metabolism
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Membrane Proteins
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Mice
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Phosphorylation
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Protein Transport / physiology
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
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Signal Transduction / physiology
Substances
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Caveolin 1
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Cavin1 protein, mouse
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Insulin
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Membrane Proteins
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RNA-Binding Proteins