PTRF triggers a cave in

Cell. 2008 Jan 11;132(1):23-4. doi: 10.1016/j.cell.2007.12.021.

Abstract

Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae flatten and caveolin-1 is released into the cell membrane, where it is rapidly internalized and degraded.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Caveolae / metabolism*
  • Caveolae / ultrastructure
  • Caveolin 1 / metabolism
  • Cell Membrane / metabolism*
  • Cell Membrane / ultrastructure
  • Endocytosis / physiology
  • Humans
  • Insulin / metabolism
  • Membrane Proteins
  • Mice
  • Phosphorylation
  • Protein Transport / physiology
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Signal Transduction / physiology

Substances

  • Caveolin 1
  • Cavin1 protein, mouse
  • Insulin
  • Membrane Proteins
  • RNA-Binding Proteins