Should patients with type 2 diabetes and raised liver enzymes be referred for further evaluation of liver disease?

Diabetes Res Clin Pract. 2008 Apr;80(1):e10-2. doi: 10.1016/j.diabres.2007.11.016. Epub 2008 Jan 9.

Abstract

Raised liver enzymes are common in type 2 diabetes (T2DM) but often considered benign. Non-alcoholic fatty liver was the cause in 65% of cases but other causes included alcoholic liver disease and viral hepatitis. Cirrhosis was identified in 11 patients. There is a significant burden of advanced liver diseases from a variety of aetiologies in patients with T2DM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alanine Transaminase / blood
  • Aspartate Aminotransferases / blood
  • Biopsy
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Fatty Liver / epidemiology
  • Fatty Liver / metabolism
  • Fatty Liver / pathology
  • Hepatitis, Viral, Human / epidemiology
  • Hepatitis, Viral, Human / metabolism
  • Hepatitis, Viral, Human / pathology
  • Humans
  • Liver Cirrhosis / epidemiology
  • Liver Cirrhosis / metabolism
  • Liver Cirrhosis / pathology
  • Liver Diseases* / epidemiology
  • Liver Diseases* / metabolism
  • Liver Diseases* / pathology
  • Liver Diseases, Alcoholic / epidemiology
  • Liver Diseases, Alcoholic / metabolism
  • Liver Diseases, Alcoholic / pathology
  • Middle Aged
  • Prevalence
  • Referral and Consultation
  • Risk Factors
  • Severity of Illness Index
  • gamma-Glutamyltransferase / blood

Substances

  • gamma-Glutamyltransferase
  • Aspartate Aminotransferases
  • Alanine Transaminase