Antimicrobial potential of Glycyrrhiza glabra roots

Vivek K Gupta; Atiya Fatima; Uzma Faridi; Arvind S Negi; Karuna Shanker; J K Kumar; Neha Rahuja; Suaib Luqman; Brijesh S Sisodia; Dharmendra Saikia; M P Darokar; Suman P S Khanuja

doi:10.1016/j.jep.2007.11.037

Antimicrobial potential of Glycyrrhiza glabra roots

J Ethnopharmacol. 2008 Mar 5;116(2):377-80. doi: 10.1016/j.jep.2007.11.037. Epub 2007 Dec 4.

Authors

Vivek K Gupta¹, Atiya Fatima, Uzma Faridi, Arvind S Negi, Karuna Shanker, J K Kumar, Neha Rahuja, Suaib Luqman, Brijesh S Sisodia, Dharmendra Saikia, M P Darokar, Suman P S Khanuja

Affiliation

¹ Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India.

PMID: 18182260
DOI: 10.1016/j.jep.2007.11.037

Abstract

The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500 microg/mL concentration. Bioactivity guided phytochemical analysis identified glabridin as potentially active against both Mycobacterium tuberculosis H(37)Ra and H(37)Rv strains at 29.16 microg/mL concentration. It exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria. Our results indicate potential use of licorice as antitubercular agent through systemic experiments and sophisticated anti-TB assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Glycyrrhiza / chemistry*
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Plant Extracts / pharmacology*
Plant Roots / chemistry*

Substances

Anti-Bacterial Agents
Plant Extracts