Synthesis of novel pyrimidine fused 8-membered heterocycles via iminium ion cyclization reactions

Xin Che; Lianyou Zheng; Qun Dang; Xu Bai

doi:10.1021/jo7020746

Synthesis of novel pyrimidine fused 8-membered heterocycles via iminium ion cyclization reactions

J Org Chem. 2008 Feb 1;73(3):1147-9. doi: 10.1021/jo7020746. Epub 2008 Jan 8.

Authors

Xin Che¹, Lianyou Zheng, Qun Dang, Xu Bai

Affiliation

¹ The Center for Combinatorial Chemistry and Drug Discovery, Jilin University, 75 Haiwai Street, Changchun, Jilin 130012, PR China.

PMID: 18179230
DOI: 10.1021/jo7020746

Abstract

Novel tricyclic pyrimidine-fused 8-membered heterocycles were prepared by an iminium ion cyclization using pyrimidinediamine systems with electron-rich aromatic rings.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzene / chemistry
Cyclization
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / chemistry
Hydrocarbons, Chlorinated / chemistry
Imines / chemistry*
Indoles / chemistry
Ions / chemistry
Molecular Structure
Pyrimidines / chemistry*

Substances

Heterocyclic Compounds
Hydrocarbons, Chlorinated
Imines
Indoles
Ions
Pyrimidines
Benzene
pyrimidine