Enhancing the potency of therapeutic monoclonal antibodies via Fc optimization

Adv Enzyme Regul. 2008:48:152-64. doi: 10.1016/j.advenzreg.2007.11.011. Epub 2007 Dec 3.
No abstract available

Publication types

  • Validation Study

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Antibody-Dependent Cell Cytotoxicity / genetics
  • Immunoglobulin Fc Fragments / genetics
  • Immunoglobulin Fc Fragments / physiology*
  • Immunoglobulin G / metabolism
  • Lymphoma, B-Cell / drug therapy
  • Mice
  • Neoplasms, Experimental / drug therapy
  • Protein Engineering
  • Receptors, Fc / physiology*
  • Receptors, IgG / immunology
  • Recombinant Fusion Proteins / metabolism
  • Saccharomyces cerevisiae / metabolism

Substances

  • Antibodies, Monoclonal
  • Fc gamma receptor IIB
  • Immunoglobulin Fc Fragments
  • Immunoglobulin G
  • Receptors, Fc
  • Receptors, IgG
  • Recombinant Fusion Proteins