Abstract
Two new butanolides, subamolide D (1) and subamolide E (2), and a new secobutanolide, secosubamolide A (3), along with 21 known compounds were isolated from the leaves of Cinnamomum subavenium. The structures of 1-3 were determined by spectroscopic analysis. Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells and it was found that 1 and 2 caused DNA damage in a dose- and time-dependent manner.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
4-Butyrolactone* / analogs & derivatives
-
4-Butyrolactone* / chemistry
-
4-Butyrolactone* / isolation & purification
-
4-Butyrolactone* / pharmacology
-
Antineoplastic Agents, Phytogenic* / chemistry
-
Antineoplastic Agents, Phytogenic* / isolation & purification
-
Antineoplastic Agents, Phytogenic* / pharmacology
-
Cell Cycle / drug effects
-
Cinnamomum / chemistry*
-
DNA Damage
-
Drug Screening Assays, Antitumor
-
Humans
-
Molecular Structure
-
Plant Leaves / chemistry
-
Plants, Medicinal / chemistry*
-
Taiwan
Substances
-
Antineoplastic Agents, Phytogenic
-
secosubamolide A
-
subamolide D
-
subamolide E
-
4-Butyrolactone