Abstract
A reductive transformation of the peroxide products of ozonolysis of derivatives of 3beta-O-acetyl-22(17-->28)-abeo-lupa-17(28),20(29)-diene and the subsequent intramolecular ketalization led to a compound with a trioxane fragment. This is a new approach to a skeletal modification of triterpenoid cycle E. An activity of the synthesized compounds was found toward the viruses of type A influenza and herpes simplex.
MeSH terms
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Alphainfluenzavirus / drug effects*
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology*
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Catalysis
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Humans
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Ruthenium Compounds / chemistry
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Saponins / chemistry
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Simplexvirus / drug effects*
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Triterpenes / chemical synthesis
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Triterpenes / chemistry*
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Triterpenes / pharmacology*
Substances
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Antiviral Agents
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Ruthenium Compounds
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Saponins
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Triterpenes
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lupane
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ruthenium tetraoxide