Abstract
To impart antimicrobial activity to surgical sutures, weaved polyester fibers are coated with poly-3-hydroxybutyrate (PHB), containing the antimicrobial agent furazolidone (FZ). The prolonged FZ effect (7-14 days) is achieved by two-step application of a sheath, constituting 10% of the suture weight and containing 2-6% FZ. The sheath structure and antimicrobial activity of sutures can be modified by the introduction of other biocompatible and biodegradable polymers.
MeSH terms
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Anti-Infective Agents, Local / chemistry
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Anti-Infective Agents, Local / pharmacology*
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Coated Materials, Biocompatible / chemistry*
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Coated Materials, Biocompatible / pharmacology*
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Furazolidone / chemistry
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Furazolidone / pharmacology*
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Hydroxybutyrates / chemistry*
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Materials Testing
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Polyesters / chemistry*
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Staphylococcus aureus / drug effects
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Sutures*
Substances
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Anti-Infective Agents, Local
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Coated Materials, Biocompatible
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Hydroxybutyrates
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Polyesters
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poly-beta-hydroxybutyrate
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Furazolidone