Abstract
Thirteen patients (age 38-67 years) with primary lymphoma of the central nervous system (CNS) were treated with methotrexate and cytarabine/thiotepa induction-chemotherapy followed by high-dose carmustine/thiotepa and autologous stem-cell transplantation. Radiotherapy was restricted to patients who did not respond completely to chemotherapy. With a median follow up of 25 months, 3-year DFS and OS was 77%.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Central Nervous System Neoplasms / drug therapy*
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Central Nervous System Neoplasms / radiotherapy*
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Central Nervous System Neoplasms / therapy
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Combined Modality Therapy / methods*
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Disease-Free Survival
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Female
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Humans
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Lymphoma / drug therapy*
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Lymphoma / radiotherapy*
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Lymphoma / therapy
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Male
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Methotrexate / administration & dosage
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Middle Aged
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Stem Cell Transplantation / methods*
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Transplantation, Autologous / methods*
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Treatment Outcome