High-dose chemotherapy and autologous stem-cell transplantation without consolidating radiotherapy as first-line treatment for primary lymphoma of the central nervous system

Haematologica. 2008 Jan;93(1):147-8. doi: 10.3324/haematol.11771.

Abstract

Thirteen patients (age 38-67 years) with primary lymphoma of the central nervous system (CNS) were treated with methotrexate and cytarabine/thiotepa induction-chemotherapy followed by high-dose carmustine/thiotepa and autologous stem-cell transplantation. Radiotherapy was restricted to patients who did not respond completely to chemotherapy. With a median follow up of 25 months, 3-year DFS and OS was 77%.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Central Nervous System Neoplasms / drug therapy*
  • Central Nervous System Neoplasms / radiotherapy*
  • Central Nervous System Neoplasms / therapy
  • Combined Modality Therapy / methods*
  • Disease-Free Survival
  • Female
  • Humans
  • Lymphoma / drug therapy*
  • Lymphoma / radiotherapy*
  • Lymphoma / therapy
  • Male
  • Methotrexate / administration & dosage
  • Middle Aged
  • Stem Cell Transplantation / methods*
  • Transplantation, Autologous / methods*
  • Treatment Outcome

Substances

  • Methotrexate