Cancer is one of the most feared diseases in the world. The fear of this disease contributes to the grief experienced after the diagnosis. The patient, family members, caregivers, and physicians experience this grief, which has many dimensions and can be extremely complicated. Grief is expressed differently by different cultures, and faith can help in dealing with grief, but no one can escape the emotional, psychological, and spiritual pain associated with the grief individuals feel when they suffer a loss. For this reason, it is best to have a holistic approach when caring for those who are grieving to more effectively meet their needs and to bring hope and healing into a very painful experience. Two case presentations illustrate the application of the hospice approach to grieving patients and the complexity of their grief.